Neuronal migration
نویسندگان
چکیده
منابع مشابه
Neuronal migration
Like other motile cells, neurons migrate in three schematic steps, namely leading edge extension, nuclear translocation or nucleokinesis, and retraction of the trailing process. In addition, neurons are ordered into architectonic patterns at the end of migration. Leading edge extension can proceed at the extremity of the axon, by growth cone formation, or from the dendrites, by formation of den...
متن کاملNeuronal Migration
ENCYCLOPEDIA OF LIFE SCIENCES July 2002 ©Macmillan Reference Ltd Neuronal Migration Introductory Structures and Processes Developmental Biology Author to provide list of keywords Wong, Kit Kit Wong Washington University School of Medicine, St. Louis, Missouri, USA Wu, Jane Y Jane Y Wu Washington University School of Medicine, St. Louis, Missouri, USA Rao, Yi Yi Rao Washington University School ...
متن کاملNucleokinesis in Neuronal Migration
Neuronal migration is a critical phase of nervous system development and can be divided into two distinct phases: extension of the leading process and movement of the cell body and nucleus (nucleokinesis). Nucleokinesis appears to require many of the same cytoskeletal and signaling molecules used in cell mitosis. Converging studies suggest it requires cytoplasmic dynein, cell polarity genes, an...
متن کاملmPar6 Controls Neuronal Migration
We review studies on the polarity of developing cerebellar granule, showing that the centrosome localizes to the pole of the neuron that extrudes the nascent axon, and the Rho GTPase Cdc42 (cell division cycle 42) activates the mPar6 /Par3 (Par for partitioning defective) complex to coordinate actin dynamics in the growth cone. Subsequently, mPar6 signaling controls the migration of immature gr...
متن کاملDisorders of neuronal migration.
Neuronal migration constitutes one of the major processes by which the central nervous system takes shape. Detailed knowledge about this important process now exists for different brain regions in rodent and monkey models as well as in the human. In the human, distinct genetic, chromosomal and environmental causes are known that affect neuronal migration, often in a morphologically distinct pat...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2001
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(01)00396-3